Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation

The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including pharmaceutical compounds, environmental contaminants, and natural products, to induce transcriptional events that regulate drug detoxification a...

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Detalles Bibliográficos
Publicado en:J Pharmacol Exp Ther
Main Authors: Hudson, Grace, Flannigan, Kyle L., Venu, Vivek Krishna Pulakazhi, Alston, Laurie, Sandall, Christina F., MacDonald, Justin A., Muruve, Daniel A., Chang, Thomas K.H., Mani, Sridhar, Hirota, Simon A.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Inflammation, Immunopharmacology, and Asthma
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542184/
https://ncbi.nlm.nih.gov/pubmed/31004077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.255679
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