The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins

Clostridioides difficile (formerly Clostridium difficile; C difficile), the leading cause of nosocomial antibiotic‐associated colitis and diarrhea in the industrialized world, triggers colonic disease through the release two toxins, toxin A (TcdA) and toxin B (TcdB), glucosyltransferases that modula...

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Veröffentlicht in:FASEB J
Hauptverfasser: Erickson, Sarah L., Alston, Laurie, Nieves, Kristoff, Chang, Thomas K. H., Mani, Sridhar, Flannigan, Kyle L., Hirota, Simon A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027580/
https://ncbi.nlm.nih.gov/pubmed/31907988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902083RR
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