A119 THE MICROBIAL METABOLITE SENSOR PREGNANE X RECEPTOR (PXR) RESTRAINS FIBROBLASTS FROM PROMOTING INTESTINAL INFLAMMATION AND FIBROSIS IN MICE

BACKGROUND: Fibrosis contributes to intestinal stricture and obstruction in 30–50% of Crohn’s disease patients. The pathogenesis of fibrosis is incompletely understood and has virtually no effective treatments. The pregnane X receptor (PXR), a xenobiotic receptor involved in detoxification responses...

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Bibliografiset tiedot
Julkaisussa:J Can Assoc Gastroenterol
Päätekijät: Flannigan, K L, Alston, L, Mani, S, Hirota, S A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2018
Aiheet:
Poster Presentations
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6507898/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwy008.120
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