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A119 THE MICROBIAL METABOLITE SENSOR PREGNANE X RECEPTOR (PXR) RESTRAINS FIBROBLASTS FROM PROMOTING INTESTINAL INFLAMMATION AND FIBROSIS IN MICE
BACKGROUND: Fibrosis contributes to intestinal stricture and obstruction in 30–50% of Crohn’s disease patients. The pathogenesis of fibrosis is incompletely understood and has virtually no effective treatments. The pregnane X receptor (PXR), a xenobiotic receptor involved in detoxification responses...
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| Publicado no: | J Can Assoc Gastroenterol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6507898/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwy008.120 |
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