Targeting the pregnane X receptor using microbial metabolite mimicry

The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that established microbial (indole) metabolites as PXR ligands, we pro...

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Publié dans:EMBO Mol Med
Auteurs principaux: Dvořák, Zdeněk, Kopp, Felix, Costello, Cait M, Kemp, Jazmin S, Li, Hao, Vrzalová, Aneta, Štěpánková, Martina, Bartoňková, Iveta, Jiskrová, Eva, Poulíková, Karolína, Vyhlídalová, Barbora, Nordstroem, Lars U, Karunaratne, Chamini V, Ranhotra, Harmit S, Mun, Kyu Shik, Naren, Anjaparavanda P, Murray, Iain A, Perdew, Gary H, Brtko, Julius, Toporova, Lucia, Schön, Arne, Wallace, Bret D, Walton, William G, Redinbo, Matthew R, Sun, Katherine, Beck, Amanda, Kortagere, Sandhya, Neary, Michelle C, Chandran, Aneesh, Vishveshwara, Saraswathi, Cavalluzzi, Maria M, Lentini, Giovanni, Cui, Julia Yue, Gu, Haiwei, March, John C, Chatterjee, Shirshendu, Matson, Adam, Wright, Dennis, Flannigan, Kyle L, Hirota, Simon A, Sartor, Ryan Balfour, Mani, Sridhar
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136958/
https://ncbi.nlm.nih.gov/pubmed/32153125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201911621
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