Targeting the pregnane X receptor using microbial metabolite mimicry

The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that established microbial (indole) metabolites as PXR ligands, we pro...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Dvořák, Zdeněk, Kopp, Felix, Costello, Cait M, Kemp, Jazmin S, Li, Hao, Vrzalová, Aneta, Štěpánková, Martina, Bartoňková, Iveta, Jiskrová, Eva, Poulíková, Karolína, Vyhlídalová, Barbora, Nordstroem, Lars U, Karunaratne, Chamini V, Ranhotra, Harmit S, Mun, Kyu Shik, Naren, Anjaparavanda P, Murray, Iain A, Perdew, Gary H, Brtko, Julius, Toporova, Lucia, Schön, Arne, Wallace, Bret D, Walton, William G, Redinbo, Matthew R, Sun, Katherine, Beck, Amanda, Kortagere, Sandhya, Neary, Michelle C, Chandran, Aneesh, Vishveshwara, Saraswathi, Cavalluzzi, Maria M, Lentini, Giovanni, Cui, Julia Yue, Gu, Haiwei, March, John C, Chatterjee, Shirshendu, Matson, Adam, Wright, Dennis, Flannigan, Kyle L, Hirota, Simon A, Sartor, Ryan Balfour, Mani, Sridhar
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136958/
https://ncbi.nlm.nih.gov/pubmed/32153125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201911621
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados