The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection

Por Sun, Xingmin, Hirota, Simon A.
Publicado no Mol Immunol (2014)

Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity

Por Ranhotra, Harmit S., Flannigan, Kyle L., Brave, Martina, Mukherjee, Subhajit, Lukin, Dana J., Hirota, Simon A., Mani, Sridhar
Publicado no Nucl Receptor Res (2016)

Giardia duodenalis Infection Reduces Granulocyte Infiltration in an In Vivo Model of Bacterial Toxin-Induced Colitis and Attenuates Inflammation in Human Intestinal Tissue

Por Cotton, James A., Motta, Jean-Paul, Schenck, L. Patrick, Hirota, Simon A., Beck, Paul L., Buret, Andre G.
Publicado em 2014

Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and...

Por Garg, Aditya, Zhao, Angela, Erickson, Sarah L., Mukherjee, Subhajit, Lau, Aik Jiang, Alston, Laurie, Chang, Thomas K. H., Mani, Sridhar, Hirota, Simon A.
Publicado no J Pharmacol Exp Ther (2016)

Changes in Composition of the Gut Bacterial Microbiome after Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in a Pediatric Heart Transplant Patient

Por Flannigan, Kyle L., Rajbar, Taylor, Moffat, Andrew, McKenzie, Leanna S., Dicke, Frank, Rioux, Kevin, Workentine, Matthew L., Louie, Thomas J., Hirota, Simon A., Greenway, Steven C.
Publicado no Front Cardiovasc Med (2017)

Heat shock protein‐27 and sex‐selective regulation of muscarinic and proteinase‐activated receptor 2‐mediated vasodilatation: differential sensitivity to endothelial NOS inhibition...

Por Pulakazhi Venu, Vivek Krishna, Saifeddine, Mahmoud, Mihara, Koichiro, El‐Daly, Mahmoud, Belke, Darrell, Dean, Jonathan L E, O'Brien, Edward R, Hirota, Simon A, Hollenberg, Morley D
Publicado no Br J Pharmacol (2018)

Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice

Por Hirota, Simon A., Ueno, Aito, Tulk, Sarah E., Becker, Helen M., Schenck, L. Patrick, Potentier, Mireille S., Li, Yan, Ghosh, Subrata, Muruve, Daniel A., MacDonald, Justin A., Beck, Paul L.
Publicado no Mediators Inflamm (2016)

IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria

Por Flannigan, Kyle L., Ngo, Vu L., Geem, Duke, Harusato, Akihito, Hirota, Simon A., Parkos, Charles A., Lukacs, Nicholas W., Nusrat, Asma, Gaboriau-Routhiau, Valérie, Cerf-Bensussan, Nadine, Gewirtz, Andrew T., Denning, Timothy L.
Publicado no Mucosal Immunol (2016)

Constitutive androstane receptor regulates the intestinal mucosal response to injury

Por Hudson, Grace M, Flannigan, Kyle L, Erickson, Sarah L, Vicentini, Fernando A, Zamponi, Alexandra, Hirota, Christina L, Alston, Laurie, Altier, Christophe, Ghosh, Subrata, Rioux, Kevin P, Mani, Sridhar, Chang, Thomas K, Hirota, Simon A
Publicado no Br J Pharmacol (2017)

Activation of neuronal P2X7 receptor-Pannexin-1 mediates death of enteric neurons during colitis

Por Gulbransen, Brian D., Bashashati, Mohammad, Hirota, Simon A., Gui, Xianyong, Roberts, Jane A., MacDonald, Justin A., Muruve, Daniel A., McKay, Derek M., Beck, Paul L., Mawe, Gary M., Thompson, Roger J., Sharkey, Keith A.
Publicado em 2012

The P2Y(6) Receptor Mediates Clostridium difficile Toxin-Induced CXCL8/IL-8 Production and Intestinal Epithelial Barrier Dysfunction

Por Hansen, Ashleigh, Alston, Laurie, Tulk, Sarah E., Schenck, L. Patrick, Grassie, Michael E., Alhassan, Basmah F., Veermalla, Arun Teja, Al-Bashir, Samir, Gendron, Fernand-Pierre, Altier, Christophe, MacDonald, Justin A., Beck, Paul L., Hirota, Simon A.
Publicado em 2013

The NLRP3 inflammasome plays key role in the regulation of intestinal homeostasis

Por Hirota, Simon A., Ng, Jeffrey, Lueng, Alan, Khajah, Maitham, Parhar, Ken, Li, Yan, Lam, Victor, Potentier, Mireille S., Ng, Kelvin, Bawa, Misha, McCafferty, Donna-Marie, Rioux, Kevin P., Ghosh, Subrata, Xavier, Ramnik J., Colgan, Sean P., Tschopp, Jurg, Muruve, Daniel, MacDonald, Justin A., Beck, Paul L.
Publicado em 2010

Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury

Por Hirota, Simon A., Fines, Kyla, Ng, Jeffery, Traboulsi, Danya, Lee, Josh, Ihara, Eikichi, Li, Yan, Willmore, William G., Chung, Daniel, Scully, Melanie M., Louie, Thomas, Medlicott, Sean, Lejeune, Manigandan, Chadee, Kris, Armstrong, Glen, Colgan, Sean P., Muruve, Daniel A., MacDonald, Justin A., Beck, Paul L.
Publicado em 2010

Intrarectal Instillation of Clostridium difficile Toxin A Triggers Colonic Inflammation and Tissue Damage: Development of a Novel and Efficient Mouse Model of Clostridium difficile...

Por Hirota, Simon A., Iablokov, Vadim, Tulk, Sarah E., Schenck, L. Patrick, Becker, Helen, Nguyen, Jimmie, Al Bashir, Samir, Dingle, Tanis C., Laing, Austin, Liu, Jianrui, Li, Yan, Bolstad, Jeff, Mulvey, George L., Armstrong, Glen D., MacNaughton, Wallace K., Muruve, Daniel A., MacDonald, Justin A., Beck, Paul L.
Publicado em 2012