Intrarectal Instillation of Clostridium difficile Toxin A Triggers Colonic Inflammation and Tissue Damage: Development of a Novel and Efficient Mouse Model of Clostridium difficile Toxin Exposure

Clostridium difficile, a major cause of hospital-acquired diarrhea, triggers disease through the release of two toxins, toxin A (TcdA) and toxin B (TcdB). These toxins disrupt the cytoskeleton of the intestinal epithelial cell, increasing intestinal permeability and triggering the release of inflamm...

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Autores principales: Hirota, Simon A., Iablokov, Vadim, Tulk, Sarah E., Schenck, L. Patrick, Becker, Helen, Nguyen, Jimmie, Al Bashir, Samir, Dingle, Tanis C., Laing, Austin, Liu, Jianrui, Li, Yan, Bolstad, Jeff, Mulvey, George L., Armstrong, Glen D., MacNaughton, Wallace K., Muruve, Daniel A., MacDonald, Justin A., Beck, Paul L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Host Response and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497439/
https://ncbi.nlm.nih.gov/pubmed/23045481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00933-12
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