Intrarectal Instillation of Clostridium difficile Toxin A Triggers Colonic Inflammation and Tissue Damage: Development of a Novel and Efficient Mouse Model of Clostridium difficile Toxin Exposure

Clostridium difficile, a major cause of hospital-acquired diarrhea, triggers disease through the release of two toxins, toxin A (TcdA) and toxin B (TcdB). These toxins disrupt the cytoskeleton of the intestinal epithelial cell, increasing intestinal permeability and triggering the release of inflamm...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Hirota, Simon A., Iablokov, Vadim, Tulk, Sarah E., Schenck, L. Patrick, Becker, Helen, Nguyen, Jimmie, Al Bashir, Samir, Dingle, Tanis C., Laing, Austin, Liu, Jianrui, Li, Yan, Bolstad, Jeff, Mulvey, George L., Armstrong, Glen D., MacNaughton, Wallace K., Muruve, Daniel A., MacDonald, Justin A., Beck, Paul L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Host Response and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497439/
https://ncbi.nlm.nih.gov/pubmed/23045481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00933-12
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi