Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation

The inflammatory bowel diseases (IBDs) are chronic inflammatory disorders with a complex etiology. IBD is thought to arise in genetically susceptible individuals in the context of aberrant interactions with the intestinal microbiota and other environmental risk factors. Recently, the pregnane X rece...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Garg, Aditya, Zhao, Angela, Erickson, Sarah L., Mukherjee, Subhajit, Lau, Aik Jiang, Alston, Laurie, Chang, Thomas K. H., Mani, Sridhar, Hirota, Simon A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034705/
https://ncbi.nlm.nih.gov/pubmed/27440420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.234096
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