Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation

Human pregnane X receptor (PXR) has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Rifaximin, a human PXR activator, is in clinical trials for treatment of IBD and has demonstrated efficacy in Crohn's disease and active ulcerative colitis. In the current study, the pro...

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Hlavní autoři: Cheng, Jie, Shah, Yatrik M., Ma, Xiaochao, Pang, Xiaoyan, Tanaka, Toshiya, Kodama, Tatsuhiko, Krausz, Kristopher W., Gonzalez, Frank J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2010
Témata:
Gastrointestinal, Hepatic, Pulmonary, and Renal
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957776/
https://ncbi.nlm.nih.gov/pubmed/20627999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.170225
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