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Role of the Pregnane X Receptor in Binge Ethanol-Induced Steatosis and Hepatotoxicity
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-sensing nuclear receptor that defends against toxic agents. We have shown that PXR promotes chronic ethanol (EtOH)–induced steatosis. Therefore, we examined the role of PXR in binge EtOH-induced hepatotoxicity. Male wild-type (WT) and Pxr-null mic...
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| Publicat a: | J Pharmacol Exp Ther |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7934678/ https://ncbi.nlm.nih.gov/pubmed/29431616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.244665 |
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