Role of the Pregnane X Receptor in Binge Ethanol-Induced Steatosis and Hepatotoxicity

The pregnane X receptor (PXR, NR1I2) is a xenobiotic-sensing nuclear receptor that defends against toxic agents. We have shown that PXR promotes chronic ethanol (EtOH)–induced steatosis. Therefore, we examined the role of PXR in binge EtOH-induced hepatotoxicity. Male wild-type (WT) and Pxr-null mic...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Choi, Sora, Gyamfi, Afua A., Neequaye, Prince, Addo, Samuel, Gonzalez, Frank J., Gyamfi, Maxwell A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2018
Fag:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934678/
https://ncbi.nlm.nih.gov/pubmed/29431616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.244665
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