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Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor

Novel methylindoles were identified as endobiotic and xenobiotic ligands of the human aryl hydrocarbon receptor (AhR). We examined the effects of 22 methylated and methoxylated indoles on the transcriptional activity of AhRs. Employing reporter gene assays in AZ-AHR transgenic cells, we determined f...

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Pubblicato in:Mol Pharmacol
Autori principali: Stepankova, Martina, Bartonkova, Iveta, Jiskrova, Eva, Vrzal, Radim, Mani, Sridhar, Kortagere, Sandhya, Dvorak, Zdenek
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941192/
https://ncbi.nlm.nih.gov/pubmed/29626056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112151
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