Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization

We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low-potency agonists of human AhR. The efficacy of catabolites differed substantially, comprising agonists with no or low (...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Vyhlídalová, Barbora, Krasulová, Kristýna, Pečinková, Petra, Marcalíková, Adéla, Vrzal, Radim, Zemánková, Lenka, Vančo, Jan, Trávníček, Zdeněk, Vondráček, Jan, Karasová, Martina, Mani, Sridhar, Dvořák, Zdeněk
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7177849/
https://ncbi.nlm.nih.gov/pubmed/32283770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072614
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