Enantiospecific Effects of Ketoconazole on Aryl Hydrocarbon Receptor

Azole antifungal ketoconazole (KET) was demonstrated to activate aryl hydrocarbon receptor (AhR). Since clinically used KET is a racemic mixture of two cis-enantiomers (2R,4S)-(+)-KET and (2S,4R)-(−)-KET, we examined the effects of KET enantiomers on AhR signaling pathway. (+)-KET dose-dependently a...

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Detalhes bibliográficos
Main Authors: Novotna, Aneta, Korhonova, Martina, Bartonkova, Iveta, Soshilov, Anatoly A., Denison, Michael S., Bogdanova, Katerina, Kolar, Milan, Bednar, Petr, Dvorak, Zdenek
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084896/
https://ncbi.nlm.nih.gov/pubmed/25000292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101832
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