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The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome
Sterile inflammation is a cornerstone of immune activation in obesity and type 2 Diabetes Mellitus. The molecular underpinnings of this inflammation include nutrient excess-mediated activation of the innate immune NLRP3 inflammasome. At the same time, disruption of mitochondrial integrity is emergin...
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| Publicado no: | Cell Mol Life Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5391300/ https://ncbi.nlm.nih.gov/pubmed/27942750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-016-2431-7 |
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