Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

Twenty-four hours of fasting is known to blunt activation of the human NLRP3 inflammasome. This effect might be mediated by SIRT3 activation, controlling mitochondrial reactive oxygen species. To characterize the molecular underpinnings of this fasting effect, we comparatively analyzed the NLRP3 inf...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Traba, Javier, Geiger, Sarah S., Kwarteng-Siaw, Miriam, Han, Kim, Ra, One Hyuk, Siegel, Richard M., Gius, David, Sack, Michael N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519366/
https://ncbi.nlm.nih.gov/pubmed/28584055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.791715
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