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The binding orientation of epibatidine at α7 nACh receptors

Epibatidine is an alkaloid toxin that binds with high affinity to nicotinic and muscarinic acetylcholine receptors, and has been extensively used as a research tool. To examine binding interactions at the nicotinic receptor, it has been co-crystallised with the structural homologue acetylcholine bin...

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Pubblicato in:Neuropharmacology
Autori principali: Thompson, Andrew J., Metzger, Simon, Lochner, Martin, Ruepp, Marc-David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Pergamon Press 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390772/
https://ncbi.nlm.nih.gov/pubmed/28089847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.01.008
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