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Synthesis of desformylflustrabromine and its evaluation as an α4β2 and α7 nACh receptor modulator

Desformylflustrabromine (dFBr; 1) and desformylflustrabromine-B (dFBr-B; 2) have been previously isolated from natural sources, and the former has been demonstrated to be a novel and selective positive allosteric modulator of α4β2 nicotinic acetylcholine (nACh) receptors. The present study describes...

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Detalhes bibliográficos
Main Authors: Kim, Jin-Sung, Padnya, Anshul, Weltzin, Maegan, Edmonds, Brian W., Schulte, Marvin K., Glennon, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633077/
https://ncbi.nlm.nih.gov/pubmed/17604168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.06.047
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