Deconstruction of the α4β2 Nicotinic Acetylchloine (nACh) Receptor Positive Allosteric Modulator des-Formylflustrabromine (dFBr)

des -Formylflustrabromine (dFBr; 1), perhaps the first selective positive allosteric modulator of α4β2 neuronal nicotinic acetylcholine (nACh) receptors, was deconstructed to determine which structural features contribute to its actions on receptors expressed in Xenopus ooycytes using 2-electrode vo...

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Bibliografische gegevens
Hoofdauteurs: German, Nadezhda, Kim, Jin-Sung, Jain, Atul, Dukat, Malgorzata, Pandya, Anshul, Ma, Yilong, Weltzin, Maegan, Schulte, Marvin K., Glennon, Richard A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3200116/
https://ncbi.nlm.nih.gov/pubmed/21905680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200834x
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