AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal and pathological states remains poorly understood due to the lack of selective probes. Here, we used a binding a...

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Bibliografische gegevens
Hoofdauteurs: Dutertre, Sébastien, Ulens, Chris, Büttner, Regina, Fish, Alexander, van Elk, René, Kendel, Yvonne, Hopping, Gene, Alewood, Paul F, Schroeder, Christina, Nicke, Annette, Smit, August B, Sixma, Titia K, Lewis, Richard J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2007
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952216/
https://ncbi.nlm.nih.gov/pubmed/17660751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601785
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