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AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal and pathological states remains poorly understood due to the lack of selective probes. Here, we used a binding a...

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Autores principales: Dutertre, Sébastien, Ulens, Chris, Büttner, Regina, Fish, Alexander, van Elk, René, Kendel, Yvonne, Hopping, Gene, Alewood, Paul F, Schroeder, Christina, Nicke, Annette, Smit, August B, Sixma, Titia K, Lewis, Richard J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952216/
https://ncbi.nlm.nih.gov/pubmed/17660751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601785
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