Single-cell profiling reveals that eRNA accumulation at enhancer–promoter loops is not required to sustain transcription

Enhancers are intergenic DNA elements that regulate the transcription of target genes in response to signaling pathways by interacting with promoters over large genomic distances. Recent studies have revealed that enhancers are bi-directionally transcribed into enhancer RNAs (eRNAs). Using single-mo...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Rahman, Samir, Zorca, Cornelia E., Traboulsi, Tatiana, Noutahi, Emmanuel, Krause, Matthew R., Mader, Sylvie, Zenklusen, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389544/
https://ncbi.nlm.nih.gov/pubmed/27932455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1220
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