Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cells

The CFTR gene lies within an invariant topologically associated domain (TAD) demarcated by CTCF and cohesin, but shows cell-type specific control mechanisms utilizing different cis-regulatory elements (CRE) within the TAD. Within the respiratory epithelium, more than one cell type expresses CFTR and...

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Udgivet i:Nucleic Acids Res
Main Authors: NandyMazumdar, Monali, Yin, Shiyi, Paranjapye, Alekh, Kerschner, Jenny L, Swahn, Hannah, Ge, Alex, Leir, Shih-Hsing, Harris, Ann
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144911/
https://ncbi.nlm.nih.gov/pubmed/32095812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa089
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