cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium

Signaling through cGMP has therapeutic potential in the colon, where it has been implicated in the suppression of colitis and colon cancer. In this study, we tested the ability of cGMP and type 2 cGMP-dependent protein kinase (PKG2) to activate forkhead box O (FoxO) in colon cancer cells and in the...

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Enregistré dans:
Détails bibliographiques
Publié dans:Am J Pathol
Auteurs principaux: Wang, Rui, Islam, Bianca N., Bridges, Allison, Sharman, Sarah K., Hu, Muhan, Hou, Yali, Somanath, Payaningal R., Venable, Laine, Singh, Nagendra, Kim, Sangmi, Sridhar, Subbaramiah, Hofmann, Franz, Browning, Darren D.
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2017
Sujets:
Regular Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389370/
https://ncbi.nlm.nih.gov/pubmed/27998725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.10.016
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