Sildenafil normalizes bowel transit in preclinical models of constipation

Guanylyl cyclase-C (GC-C) agonists increase cGMP levels in the intestinal epithelium to promote secretion. This process underlies the utility of exogenous GC-C agonists such as linaclotide for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-...

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Publicado en:PLoS One
Autores principales: Sharman, Sarah K., Islam, Bianca N., Hou, Yali, Usry, Margaux, Bridges, Allison, Singh, Nagendra, Sridhar, Subbaramiah, Rao, Satish, Browning, Darren D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407793/
https://ncbi.nlm.nih.gov/pubmed/28448580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176673
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