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Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium

Analysis of knockout animals indicates that 3′,5′cyclic guanosine monophosphate (cGMP) has an important role in gut homeostasis but the signaling mechanism is not known. The goals of this study were to test whether increasing cGMP could affect colon homeostasis and determine the mechanism. We increa...

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Sonraí Bibleagrafaíochta
Main Authors: Wang, R, Kwon, I-K, Singh, N, Islam, B, Liu, K, Sridhar, S, Hofmann, F, Browning, D D
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3921591/
https://ncbi.nlm.nih.gov/pubmed/24270408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.163
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