Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

In yeast, dNTP pools expand drastically during DNA damage response. We show that similar dNTP elevation occurs in strains, in which intrinsic replisome defects promote the participation of error-prone DNA polymerase ζ (Polζ) in replication of undamaged DNA. To understand the significance of dNTP poo...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Kochenova, Olga V., Bezalel-Buch, Rachel, Tran, Phong, Makarova, Alena V., Chabes, Andrei, Burgers, Peter M. J., Shcherbakova, Polina V.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388397/
https://ncbi.nlm.nih.gov/pubmed/28180291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1149
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