Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

In yeast, dNTP pools expand drastically during DNA damage response. We show that similar dNTP elevation occurs in strains, in which intrinsic replisome defects promote the participation of error-prone DNA polymerase ζ (Polζ) in replication of undamaged DNA. To understand the significance of dNTP poo...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Kochenova, Olga V., Bezalel-Buch, Rachel, Tran, Phong, Makarova, Alena V., Chabes, Andrei, Burgers, Peter M. J., Shcherbakova, Polina V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2017
Ämnen:
Genome Integrity, Repair and Replication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388397/
https://ncbi.nlm.nih.gov/pubmed/28180291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1149
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