Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

In yeast, dNTP pools expand drastically during DNA damage response. We show that similar dNTP elevation occurs in strains, in which intrinsic replisome defects promote the participation of error-prone DNA polymerase ζ (Polζ) in replication of undamaged DNA. To understand the significance of dNTP poo...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Kochenova, Olga V., Bezalel-Buch, Rachel, Tran, Phong, Makarova, Alena V., Chabes, Andrei, Burgers, Peter M. J., Shcherbakova, Polina V.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Genome Integrity, Repair and Replication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388397/
https://ncbi.nlm.nih.gov/pubmed/28180291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1149
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