Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

In yeast, dNTP pools expand drastically during DNA damage response. We show that similar dNTP elevation occurs in strains, in which intrinsic replisome defects promote the participation of error-prone DNA polymerase ζ (Polζ) in replication of undamaged DNA. To understand the significance of dNTP poo...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Kochenova, Olga V., Bezalel-Buch, Rachel, Tran, Phong, Makarova, Alena V., Chabes, Andrei, Burgers, Peter M. J., Shcherbakova, Polina V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388397/
https://ncbi.nlm.nih.gov/pubmed/28180291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1149
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