Chemosensitivity of IDH1-mutated gliomas due to an impairment in PARP1-mediated DNA repair

Mutations in isocitrate dehydrogenase (IDH) are the most prevalent genetic abnormalities in lower grade gliomas. The presence of these mutations in glioma is prognostic for better clinical outcomes with longer patient survival. In the present study, we found that defects in oxidative metabolism and...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Lu, Yanxin, Kwintkiewicz, Jakub, Liu, Yang, Tech, Katherine, Frady, Lauren N., Su, Yu-Ting, Bautista, Wendy, Moon, Seog In, MacDonald, Jeffrey, Ewend, Matthew G., Gilbert, Mark R., Yang, Chunzhang, Wu, Jing
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380481/
https://ncbi.nlm.nih.gov/pubmed/28202508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2773
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