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Chemosensitivity of IDH1-mutated gliomas due to an impairment in PARP1-mediated DNA repair

Mutations in isocitrate dehydrogenase (IDH) are the most prevalent genetic abnormalities in lower grade gliomas. The presence of these mutations in glioma is prognostic for better clinical outcomes with longer patient survival. In the present study, we found that defects in oxidative metabolism and...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Lu, Yanxin, Kwintkiewicz, Jakub, Liu, Yang, Tech, Katherine, Frady, Lauren N., Su, Yu-Ting, Bautista, Wendy, Moon, Seog In, MacDonald, Jeffrey, Ewend, Matthew G., Gilbert, Mark R., Yang, Chunzhang, Wu, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380481/
https://ncbi.nlm.nih.gov/pubmed/28202508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2773
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