Chemosensitivity of IDH1-mutated gliomas due to an impairment in PARP1-mediated DNA repair

Mutations in isocitrate dehydrogenase (IDH) are the most prevalent genetic abnormalities in lower grade gliomas. The presence of these mutations in glioma is prognostic for better clinical outcomes with longer patient survival. In the present study, we found that defects in oxidative metabolism and...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Lu, Yanxin, Kwintkiewicz, Jakub, Liu, Yang, Tech, Katherine, Frady, Lauren N., Su, Yu-Ting, Bautista, Wendy, Moon, Seog In, MacDonald, Jeffrey, Ewend, Matthew G., Gilbert, Mark R., Yang, Chunzhang, Wu, Jing
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380481/
https://ncbi.nlm.nih.gov/pubmed/28202508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2773
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