Chemosensitivity of IDH1-mutated gliomas due to an impairment in PARP1-mediated DNA repair

Mutations in isocitrate dehydrogenase (IDH) are the most prevalent genetic abnormalities in lower grade gliomas. The presence of these mutations in glioma is prognostic for better clinical outcomes with longer patient survival. In the present study, we found that defects in oxidative metabolism and...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Lu, Yanxin, Kwintkiewicz, Jakub, Liu, Yang, Tech, Katherine, Frady, Lauren N., Su, Yu-Ting, Bautista, Wendy, Moon, Seog In, MacDonald, Jeffrey, Ewend, Matthew G., Gilbert, Mark R., Yang, Chunzhang, Wu, Jing
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380481/
https://ncbi.nlm.nih.gov/pubmed/28202508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2773
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