PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

It is unclear whether PD-L1 on tumor cells is sufficient for tumor immune evasion or simply correlates with an inflamed tumor microenvironment. We used three mouse tumor models sensitive to PD-1 blockade to evaluate the significance of PD-L1 on tumor versus nontumor cells. PD-L1 on nontumor cells is...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Juneja, Vikram R., McGuire, Kathleen A., Manguso, Robert T., LaFleur, Martin W., Collins, Natalie, Haining, W. Nicholas, Freeman, Gordon J., Sharpe, Arlene H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379970/
https://ncbi.nlm.nih.gov/pubmed/28302645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160801
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