Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth

Therapeutic antibodies targeting programmed cell death-1 (PD-1) activate tumor-specific immunity and have shown remarkable efficacy in the treatment of melanoma. Yet, little is known about tumor cell-intrinsic PD-1 pathway effects. Here we show that murine and human melanomas contain PD-1-expressing...

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Bibliografiska uppgifter
I publikationen:Cell
Huvudupphovsmän: Kleffel, Sonja, Posch, Christian, Barthel, Steven R., Mueller, Hansgeorg, Schlapbach, Christoph, Guenova, Emmanuella, Elco, Christopher P., Lee, Nayoung, Juneja, Vikram R., Zhan, Qian, Lian, Christine G., Thomi, Rahel, Hoetzenecker, Wolfram, Cozzio, Antonio, Dummer, Reinhard, Mihm, Martin C., Flaherty, Keith T., Frank, Markus H., Murphy, George F., Sharpe, Arlene H., Kupper, Thomas S., Schatton, Tobias
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700833/
https://ncbi.nlm.nih.gov/pubmed/26359984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.052
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