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Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

The programmed death (PD)-1–PD-1 ligand (PD-L) pathway, which is part of the B7–CD28 family, consists of the PD-1 receptor and its two ligands PD-L1 and PD-L2. Engagement of PD-1 by its ligands inhibits immune responses, and recent work has shown that PD-1 is highly expressed on exhausted T cells du...

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Библиографические подробности
Главные авторы: Freeman, Gordon J., Wherry, E. John, Ahmed, Rafi, Sharpe, Arlene H.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2006
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118103/
https://ncbi.nlm.nih.gov/pubmed/17000870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061800
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