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Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway
T-cell exhaustion due to persistent antigen stimulation is a key feature of chronic viral infections and cancer. Programmed cell death-1 (PD-1) is a major regulator of T-cell exhaustion, and blocking the PD-1 pathway restores T-cell function and improves pathogen control and tumor eradication. Immun...
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| Udgivet i: | For Immunopathol Dis Therap |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341794/ https://ncbi.nlm.nih.gov/pubmed/28286692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1615/ForumImmunDisTher.2015014188 |
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