VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation

The vascular endothelial growth factor (VEGF) isoform VEGF165 stimulates vascular growth and hyperpermeability. Whereas blood vessel growth is essential to sustain organ health, chronic hyperpermeability causes damaging tissue edema. By combining in vivo and tissue culture models, we show here that...

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Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Fantin, Alessandro, Lampropoulou, Anastasia, Senatore, Valentina, Brash, James T., Prahst, Claudia, Lange, Clemens A., Liyanage, Sidath E., Raimondi, Claudio, Bainbridge, James W., Augustin, Hellmut G., Ruhrberg, Christiana
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379968/
https://ncbi.nlm.nih.gov/pubmed/28289053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160311
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