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Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure

Cholesterol is an important regulator of membrane protein function. However, the exact mechanisms involved in this process are still not fully understood. Here we study how the tertiary and quaternary structure of the mitochondrial translocator protein TSPO, which binds cholesterol with nanomolar af...

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Publicat a:Nat Commun
Autors principals: Jaipuria, Garima, Leonov, Andrei, Giller, Karin, Vasa, Suresh Kumar, Jaremko, Łukasz, Jaremko, Mariusz, Linser, Rasmus, Becker, Stefan, Zweckstetter, Markus
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379104/
https://ncbi.nlm.nih.gov/pubmed/28358007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14893
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