Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease

In Alzheimer disease (AD), the accumulation of amyloid beta (Aβ) begins decades before cognitive symptoms and progresses from intraneuronal material to extracellular plaques. To date, however, the precise mechanism by which the early buildup of Aβ peptides leads to cognitive dysfunction remains unkn...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Cereb Cortex
Главные авторы: Wilson, Edward N., Abela, Andrew R., Do Carmo, Sonia, Allard, Simon, Marks, Adam R., Welikovitch, Lindsay A., Ducatenzeiler, Adriana, Chudasama, Yogita, Cuello, A. Claudio
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378482/
https://ncbi.nlm.nih.gov/pubmed/26759481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhv332
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы