Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease

In Alzheimer disease (AD), the accumulation of amyloid beta (Aβ) begins decades before cognitive symptoms and progresses from intraneuronal material to extracellular plaques. To date, however, the precise mechanism by which the early buildup of Aβ peptides leads to cognitive dysfunction remains unkn...

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發表在:Cereb Cortex
Main Authors: Wilson, Edward N., Abela, Andrew R., Do Carmo, Sonia, Allard, Simon, Marks, Adam R., Welikovitch, Lindsay A., Ducatenzeiler, Adriana, Chudasama, Yogita, Cuello, A. Claudio
格式: Artigo
語言:Inglês
出版: Oxford University Press 2016
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378482/
https://ncbi.nlm.nih.gov/pubmed/26759481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhv332
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