Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease

In Alzheimer disease (AD), the accumulation of amyloid beta (Aβ) begins decades before cognitive symptoms and progresses from intraneuronal material to extracellular plaques. To date, however, the precise mechanism by which the early buildup of Aβ peptides leads to cognitive dysfunction remains unkn...

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Publicado en:Cereb Cortex
Main Authors: Wilson, Edward N., Abela, Andrew R., Do Carmo, Sonia, Allard, Simon, Marks, Adam R., Welikovitch, Lindsay A., Ducatenzeiler, Adriana, Chudasama, Yogita, Cuello, A. Claudio
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378482/
https://ncbi.nlm.nih.gov/pubmed/26759481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhv332
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