One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin

Few studies have been conducted to understand post-zygotic accumulation of mutations in cells of the healthy human body. We reprogrammed 32 skin fibroblast cells from families of donors into human induced pluripotent stem cell (hiPSC) lines. The clonal nature of hiPSC lines allows a high-resolution...

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Dades bibliogràfiques
Publicat a:Genome Res
Autors principals: Abyzov, Alexej, Tomasini, Livia, Zhou, Bo, Vasmatzis, Nikolaos, Coppola, Gianfilippo, Amenduni, Mariangela, Pattni, Reenal, Wilson, Michael, Gerstein, Mark, Weissman, Sherman, Urban, Alexander E., Vaccarino, Flora M.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378170/
https://ncbi.nlm.nih.gov/pubmed/28235832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.215517.116
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