One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin

Few studies have been conducted to understand post-zygotic accumulation of mutations in cells of the healthy human body. We reprogrammed 32 skin fibroblast cells from families of donors into human induced pluripotent stem cell (hiPSC) lines. The clonal nature of hiPSC lines allows a high-resolution...

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Bibliographic Details
Published in:Genome Res
Main Authors: Abyzov, Alexej, Tomasini, Livia, Zhou, Bo, Vasmatzis, Nikolaos, Coppola, Gianfilippo, Amenduni, Mariangela, Pattni, Reenal, Wilson, Michael, Gerstein, Mark, Weissman, Sherman, Urban, Alexander E., Vaccarino, Flora M.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378170/
https://ncbi.nlm.nih.gov/pubmed/28235832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.215517.116
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