One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin

Few studies have been conducted to understand post-zygotic accumulation of mutations in cells of the healthy human body. We reprogrammed 32 skin fibroblast cells from families of donors into human induced pluripotent stem cell (hiPSC) lines. The clonal nature of hiPSC lines allows a high-resolution...

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Bibliographische Detailangaben
Veröffentlicht in:Genome Res
Hauptverfasser: Abyzov, Alexej, Tomasini, Livia, Zhou, Bo, Vasmatzis, Nikolaos, Coppola, Gianfilippo, Amenduni, Mariangela, Pattni, Reenal, Wilson, Michael, Gerstein, Mark, Weissman, Sherman, Urban, Alexander E., Vaccarino, Flora M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378170/
https://ncbi.nlm.nih.gov/pubmed/28235832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.215517.116
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