FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders

Autism spectrum disorder (ASD) is a disorder of brain development. Most cases lack a clear etiology or genetic basis, and the difficulty of reenacting human brain development has precluded understanding of ASD pathophysiology. Here we use three-dimensional neural cultures (organoids) derived from in...

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Veröffentlicht in:Cell
Hauptverfasser: Mariani, Jessica, Coppola, Gianfilippo, Zhang, Ping, Abyzov, Alexej, Provini, Lauren, Tomasini, Livia, Amenduni, Mariangela, Szekely, Anna, Palejev, Dean, Wilson, Michael, Gerstein, Mark, Grigorenko, Elena, Chawarska, Katarzyna, Pelphrey, Kevin, Howe, James, Vaccarino, Flora M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519016/
https://ncbi.nlm.nih.gov/pubmed/26186191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.06.034
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