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Modeling human cortical development in vitro using induced pluripotent stem cells

Human induced pluripotent stem cells (hiPSCs) are emerging as a tool for understanding human brain development at cellular, molecular, and genomic levels. Here we show that hiPSCs grown in suspension in the presence of rostral neuralizing factors can generate 3D structures containing polarized radia...

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Main Authors: Mariani, Jessica, Simonini, Maria Vittoria, Palejev, Dean, Tomasini, Livia, Coppola, Gianfilippo, Szekely, Anna M., Horvath, Tamas L., Vaccarino, Flora M.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411972/
https://ncbi.nlm.nih.gov/pubmed/22761314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202944109
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