Somatic copy-number mosaicism in human skin revealed by induced pluripotent stem cells

Reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variations (CNVs)(1-4). To explore this issue, we performed a whole-genome and transcriptome analysis of 20 human iPSC lines derived from primary skin fibroblasts of 7 indi...

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Detalhes bibliográficos
Main Authors: Abyzov, Alexej, Mariani, Jessica, Palejev, Dean, Zhang, Ying, Haney, Michael Seamus, Tomasini, Livia, Ferrandino, Anthony, Belmaker, Lior A. Rosenberg, Szekely, Anna, Wilson, Michael, Kocabas, Arif, Calixto, Nathaniel E., Grigorenko, Elena L., Huttner, Anita, Chawarska, Katarzyna, Weissman, Sherman, Urban, Alexander Eckehart, Gerstein, Mark, Vaccarino, Flora M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532053/
https://ncbi.nlm.nih.gov/pubmed/23160490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11629
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