Somatic copy-number mosaicism in human skin revealed by induced pluripotent stem cells

Reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variations (CNVs)(1-4). To explore this issue, we performed a whole-genome and transcriptome analysis of 20 human iPSC lines derived from primary skin fibroblasts of 7 indi...

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主要な著者: Abyzov, Alexej, Mariani, Jessica, Palejev, Dean, Zhang, Ying, Haney, Michael Seamus, Tomasini, Livia, Ferrandino, Anthony, Belmaker, Lior A. Rosenberg, Szekely, Anna, Wilson, Michael, Kocabas, Arif, Calixto, Nathaniel E., Grigorenko, Elena L., Huttner, Anita, Chawarska, Katarzyna, Weissman, Sherman, Urban, Alexander Eckehart, Gerstein, Mark, Vaccarino, Flora M.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532053/
https://ncbi.nlm.nih.gov/pubmed/23160490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11629
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