Somatic copy-number mosaicism in human skin revealed by induced pluripotent stem cells

Reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variations (CNVs)(1-4). To explore this issue, we performed a whole-genome and transcriptome analysis of 20 human iPSC lines derived from primary skin fibroblasts of 7 indi...

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Autors principals: Abyzov, Alexej, Mariani, Jessica, Palejev, Dean, Zhang, Ying, Haney, Michael Seamus, Tomasini, Livia, Ferrandino, Anthony, Belmaker, Lior A. Rosenberg, Szekely, Anna, Wilson, Michael, Kocabas, Arif, Calixto, Nathaniel E., Grigorenko, Elena L., Huttner, Anita, Chawarska, Katarzyna, Weissman, Sherman, Urban, Alexander Eckehart, Gerstein, Mark, Vaccarino, Flora M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532053/
https://ncbi.nlm.nih.gov/pubmed/23160490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11629
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