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Developing Therapeutics for PrP Prion Diseases

The prototypical PrP prion diseases are invariably fatal, and the search for agents to treat them spans more than 30 years, with limited success. However, in the last few years, the application of high-throughput screening, medicinal chemistry, and pharmacokinetic optimization has led to important a...

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Bibliographic Details
Published in:Cold Spring Harb Perspect Med
Main Authors: Giles, Kurt, Olson, Steven H., Prusiner, Stanley B.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378016/
https://ncbi.nlm.nih.gov/pubmed/28096242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a023747
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