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Developing Therapeutics for PrP Prion Diseases

The prototypical PrP prion diseases are invariably fatal, and the search for agents to treat them spans more than 30 years, with limited success. However, in the last few years, the application of high-throughput screening, medicinal chemistry, and pharmacokinetic optimization has led to important a...

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Publicado en:Cold Spring Harb Perspect Med
Autores principales: Giles, Kurt, Olson, Steven H., Prusiner, Stanley B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378016/
https://ncbi.nlm.nih.gov/pubmed/28096242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a023747
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